Total biosynthesis antitumor nonribosomal peptides
Design and synthesis of ladder-shaped tetracyclic, heptacyclic, and decacyclic ethers and evaluation of the interaction with transmembrane proteins. Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli.
The pictet-spengler mechanism involved in the biosynthesis of tetrahydroisoquinoline antitumor antibiotics: Insight into a natural Diels-Alder reaction from the structure of macrophomate synthase. Substrate diversity of macrophomate synthase catalyzing multistep transformation from 2-pyrones to benzoates.
Occurrence of multiple forms for starch synthase II isozyme in developing seeds of kidney bean. Combinatorial generation of chemical diversity by redox enzymes in chaetoviridin biosynthesis.
Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product. Yeast-based genome mining, production and mechanistic studies of the biosynthesis of fungal polyketide and peptide natural products.
Toxins and biologically active compounds from microalgae, edited by Gian Paolo Rossini. Heterologous biosynthesis of amidated polyketides with novel cyclization regioselectivity from oxytetracycline polyketide synthase.
Current understanding and hypotheses on the biosynthesis of microalgal polyether toxins. Cloning and expression of an oligo-1,6-glucosidase gene from Arthrobacter globiformis I42 and biochemical characterization of the recombinant enzyme. Oxidative trans-to-cis isomerization of olefin in polyketide biosynthesis.
Essay on why gay marriages should be legal and synthesis of an artificial ladder-shaped polyether that interacts with glycophorin A. Identification of a gene cluster of polyether antibiotic lasalocid from Streptomyces lasaliensis.
Inoue, "A radical-based approach for the construction of the tetracyclic structure of resiniferatoxin," Chem. CRC Press, 1,